David Hafler M.D.

My laboratory focuses on the understanding of human autoimmune diseases with the theme that investigation of naturally occurring human diseases give insight into the basic processes of T cell regulation, in addition to providing fundamental understanding and development of new therapies for human diseases. The laboratory has defined immunodominant epitopes of autoantigens, and has developed new technologies to measure both functionality and frequency of autoreactive T cells. More recently, I have focused on broadly characterizing the molecular pathogenesis of the disease, both at the DNA, mRNA, and proteomic level.