Gerard Sanacora M.D., Ph.D.

My work is concentrated largely on elucidating the pathophysiological mechanisms associated with mood and other neuropsychiatric disorders. Much of my recent research has focused on identifying the contributions of the amino acid neurotransmitter systems (GABA and Glutamate) to the neurobiology of mood disorders and the mechanism of antidepressant action. Specifically, my basic science laboratory employs rodent models to explore the effects of chronic stress on cellular and molecular biology, and examines the molecular, cellular and behavioral effects of novel treatment strategies targeting these affected systems. My clinical laboratory employs novel magnetic resonance spectroscopy methodologies and pharmacological challenge paradigms to identify abnormalities in the function of the amino acid neurotransmitter systems in individuals suffering from mood and anxiety disorders.