- Professor of Radiology and Biomedical Imaging and of Biomedical Engineering
- Director, Yale Positron Emission Tomography (PET) Center
- Director of Graduate Studies, Biomedical Engineering
Field:
Expertise:
Positron emission tomography, nuclear medicine, medical imaging, drug occupancy, neuroreceptors
Description:
My research interests have concentrated on the following areas: 1) new algorithms for image reconstruction with PET, including early work with the EM algorithm, 2) development of mathematical models for novel radiopharmaceuticals to produce images of physiological parameters, 3) use of receptor-binding ligands to measure drug occupancy and neurotransmitter kinetics in the human brain by analysis of PET tracer signals, and 4) application of PET tracers in clinical and preclinical populations for the study of disease mechanisms and treatment outcomes.